Pathogenesis of Cholesterol Gallstones
نویسندگان
چکیده
منابع مشابه
Pathogenesis of Cholesterol Gallstones
Cholesterol gallstone disease is extremely common. Three major stages are recognized for stone formation, namely bile that becomes supersaturated with cholesterol, cholesterol nucleation leading to crystal formation and finally retention of the crystals in the gallbladder resulting in stone formation. Supersaturation is common but nucleation into crystals probably requires protein nucleating fa...
متن کاملPathogenesis of cholesterol and pigment gallstones: an update.
Phase separation of cholesterol crystals from supersaturated bile is still considered the key event in cholesterol gallstone formation. In this review, we will first provide a basal framework of the interactions between the sterol, bile salts and phospholipids in aqueous solutions and then summarize new developments. The hepatocytic apical membrane harbours specific transport proteins for these...
متن کاملPathogenesis of cholesterol and pigment gallstones: An update
Phase separation of cholesterol crystals from supersaturated bile is still considered the key event in cholesterol gallstone formation. In this review, we will first provide a basal framework of the interactions between the sterol, bile salts and phospholipids in aqueous solutions and then summarize new developments. The hepatocytic apical membrane harbours specific transport proteins for these...
متن کاملPathogenesis of gallstones.
Cholesterol gallstone formation is a complex process and involves phase separation of cholesterol crystals from supersaturated bile. In most cases, cholesterol hypersecretion is considered the primary event in gallstone formation. The sterol is transported through the hepatocytic canalicular membrane by ABCG5-G8. Expression of this transport protein is regulated by transcription factor Liver X ...
متن کاملEpidemiology of Cholesterol Gallstones
GASTROINTESTINAL ENDOSCOPY S165 Gallstones are extremely common in Western societies. Approximately l5% of Americans have gallstones, and approximately 650,000 to 700,000 cholecystectomies are performed every year.1. More than 98% of all biliary tract disorders are in some way related to gallstones. Symptoms and complications related to gallstones are among the most costly digestive disorders, ...
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ژورنال
عنوان ژورنال: HPB Surgery
سال: 1991
ISSN: 0894-8569
DOI: 10.1155/1991/61741